Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists.
Amongst the chemokine signalling axes involved in cancer, chemokine CXCL12 acting on chemokine receptor CXCR4 is particularly significant since it orchestrates migration NEFF N1AHA02N0B N50 Built In 59cm Warming Drawer Stainless Steel of cancer cells in a tissue-specific metastatic process.High CXCR4 tumour expression is associated with poor progno